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Cambridge IGCSE

Biology 0610

Cells, nutrition, transport, coordination, reproduction, inheritance and ecology, assessed through multiple choice, theory and practical papers.

Syllabus version: 2026–2028 syllabusChecked against the Cambridge syllabusExam year 2027 is covered by the 2026–2028 syllabus.
Subject review complete (20 Oct 2026). All 40 Biology questions were re-solved and checked against the syllabus and Cambridge mark-scheme conventions, and their auto-marking was tested with correct and incorrect answers: 21 approved as written, 19 corrected.

Weighting by paper. Some papers are alternatives (for example Core or Extended, or practical or alternative to practical), so the figures add up to more than 100%.

  • Paper 2 Multiple Choice (Extended)30%
  • Paper 4 Theory (Extended)50%
  • Paper 5 Practical Test20%
  • Paper 6 Alternative to Practical20%
Original questions40
Topics covered21/21
Papers4
Mock papers3

What is assessed

4 components on the Extended tier. Question formats: multiple choice, short answer, structured, practical, alternative to practical.

Paper 2 Multiple Choice (Extended)Extended
45 min40 marksWeighting 30%

Forty compulsory four-option multiple-choice items on the Core and Supplement content, testing AO1 and AO2; assesses grades A* to G.

What the paper looks like

Forty one-mark four-option items in 45 minutes on Core and Supplement content. More items need two steps of reasoning: interpreting data, unit conversion to micrometres, genetic ratios, or explaining in terms of water potential, kinetic energy or antibodies. Several options are partly right; read every option before choosing.

Multiple choiceCalculator permitted
Checked against the Cambridge syllabus
Paper 4 Theory (Extended)Extended
1 h 15 min80 marksWeighting 50%

Compulsory short-answer and structured questions on the Core and Supplement content, testing AO1 and AO2; assesses grades A* to G.

What the paper looks like

Six or seven longer structured questions totalling 80 marks in 1 hour 15 minutes, often 10–17 marks each with parts up to 5–6 marks. Unfamiliar contexts test Supplement ideas (negative feedback, limiting factors, codominance, genetic modification). Calculations ask for a stated number of significant figures; explanations need precise terms.

Short answerStructuredCalculator permitted
Checked against the Cambridge syllabus
Paper 5 Practical TestCore & Extended
1 h 15 min40 marksWeighting 20%

Laboratory-based questions (alternative to Paper 6) testing AO3 experimental skills across the full grade range.

What the paper looks like

Laboratory test of 40 marks in 1 hour 15 minutes, set up from Confidential Instructions. Typically one investigation (e.g. enzymes, osmosis, food tests) where you follow steps, record results in a table you draw, plot a graph and evaluate, plus observational work: a clear line drawing with a magnification calculation.

PracticalLaboratory apparatus and materials set up from the Confidential Instructions; calculator permitted
Checked against the Cambridge syllabusNo questions for this paper yet
Paper 6 Alternative to PracticalCore & Extended
1 h40 marksWeighting 20%

Written questions on experimental methods, results and planning (alternative to Paper 5) testing AO3; no experiments are carried out.

What the paper looks like

Written paper of 40 marks in 1 hour, usually two to four questions. Includes reading apparatus from diagrams, drawing a results table (quantity / unit headings, no units in cells), plotting a line graph, identifying variables and controls, a calculation to a stated precision, suggesting improvements and safety, and a 6-mark plan for an investigation.

Alternative to practicalCalculator permitted
Checked against the Cambridge syllabus

Assessment overview

From the 2026–2028 syllabus. Checked against the Cambridge syllabus

Core
Paper 1Paper 3Paper 5Paper 6
Paper 1, Paper 3 and either Paper 5 or Paper 6; grades C to G available.
Extended
Paper 2Paper 4Paper 5Paper 6
Paper 2, Paper 4 and either Paper 5 or Paper 6; grades A* to G available.
Assessment objectiveIGCSE weighting
AO1 Knowledge with understanding50%
AO2 Handling information and problem-solving30%
AO3 Experimental skills and investigations20%
Changes in this syllabus version
  • No significant changes affecting teaching compared with the 2023–2025 syllabus: same content, papers, timings, marks and weightings.
  • Version 3 (August 2026) updated the Assessment overview page; version 2 (December 2025) updated a weblink.
  • Textbooks endorsed for examination from 2023 remain suitable.
Command words used in Biology papers (14)
Calculate
work out an answer from given facts, figures or information
Compare
point out or comment on similarities and/or differences
Define
give the precise meaning of a term
Describe
state the points of a topic or give its main features and characteristics
Determine
reach an answer using the information provided
Evaluate
judge or calculate the quality, importance, amount or value of something
Explain
give reasons or purposes, make relationships clear, and say why and/or how, with supporting evidence
Give
produce an answer from a given source or from memory
Identify
name, select or recognise
Outline
set out the main points only
Predict
say what may happen, based on the information available
Sketch
make a simple freehand drawing showing the key features, with care over proportions
State
express clearly and briefly
Suggest
apply knowledge to an unfamiliar situation where several valid answers are possible, making proposals
Examiner guidance from recent reports (14)
Organisation of the organism. For magnification, measure the image in millimetres, then divide image size by magnification to find actual size; candidates often multiply instead. Keep the unit asked for, and convert mm to µm by multiplying by 1000 (Extended).
Movement into and out of cells. Osmosis is about water molecules only and always needs a partially permeable membrane. Say where water moves from and to (dilute to concentrated solution, or higher to lower water potential for Extended); do not write that sugar or salt moves by osmosis.
Biological molecules. Food tests earn marks for the reagent, any essential step and the precise positive colour: Benedict’s must be heated (brick-red), biuret turns purple, iodine turns blue-black, ethanol then water gives a milky emulsion, DCPIP decolourises.
Enzymes. Enzymes are denatured, never killed. Explain rate changes with kinetic energy and effective collisions below the optimum, and loss of active-site shape above it. Low temperatures slow enzymes but do not denature them.
Plant nutrition. When identifying a limiting factor, name the factor and use the graph as evidence: where the line rises, the variable on the x-axis is limiting; where it levels off, another factor is. Say the rate remains constant, not that it stops.
Human nutrition. A balanced diet contains all the nutrient groups, including fibre and water, in the correct proportions for the person’s age, activity and condition. Vitamin D helps the body use calcium; it is not itself a source of calcium.
Transport in plants. Check you write transpiration, not respiration. Describe graph trends using both variables and quote data with units, then explain using evaporation from mesophyll surfaces and diffusion of water vapour out of stomata.
Transport in animals. Link each structural feature to a function: thick, elastic artery walls withstand and smooth out high pressure; wide lumens and valves in veins suit low-pressure return. In a double circulation the blood passes through the heart twice per circuit of the body.
Diseases and immunity. Antibodies are specific: their shape is complementary to one antigen. Memory cells come from lymphocytes, not from antibodies. Vaccination gives active immunity; antibodies from milk or across the placenta give passive immunity. Avoid vague words such as “fight”.
Respiration. Respiration releases energy; mitochondria do not “produce” or “make” energy. Anaerobic respiration in muscles makes lactic acid only, with no carbon dioxide, while yeast makes alcohol and carbon dioxide.
Coordination and response. Use “impulses” rather than “signals” and name the sensory, relay and motor neurones in order. In temperature control, arterioles dilate or constrict; blood vessels do not move towards or away from the skin surface.
Inheritance. A full genetic diagram shows parental phenotypes and genotypes, gametes (circled), offspring genotypes, offspring phenotypes and the ratio or probability. Use the symbols given in the question and write letters clearly so dominant and recessive alleles can be distinguished.
Organisms and their environment. Name sigmoid curve phases exactly (lag, exponential/log, stationary, death) and write lag and log legibly. Energy is lost between trophic levels mainly as heat from respiration and in undigested or uneaten material; it is not “used up”.
Human influences on ecosystems. In eutrophication name the ions (nitrate or phosphate), then follow the sequence: algal growth, death, more decomposition, more aerobic respiration by bacteria, less dissolved oxygen, death of fish and other aerobic organisms.

Topic map

Practice types

Free sample questions

A student used this key to identify four arthropods, W, X, Y and Z. [table] A specimen has eight legs and a…
A student used this key to identify four arthropods, W, X, Y and Z.
stepfeatureoutcome
1athree pairs of legsW
1bmore than three pairs of legsgo to 2
2afour pairs of legs; body in two partsY
2bmore than four pairs of legsgo to 3
3atwo pairs of antennae; body covered by a hard shellX
3bone pair of antennae; long body of many similar segmentsZ
A specimen has eight legs and a body divided into two parts. Which letter identifies the specimen, and to which group of arthropods does it belong?
  1. X – crustacean
  2. Y – arachnid
  3. Y – insect
  4. Z – myriapod

Answer: B. Y – arachnid

Eight legs = four pairs, so step 1b leads to step 2, and “four pairs of legs; body in two parts” gives Y. Four pairs of legs and two body parts are the features of arachnids (e.g. spiders). Insects have three pairs of legs and three body parts; crustaceans have two pairs of antennae; myriapods have many segments.

A drawing of a cheek cell is 54 mm long. The magnification of the drawing is ×900. What is the actual length…
A drawing of a cheek cell is 54 mm long. The magnification of the drawing is ×900.
What is the actual length of the cell?
  1. 0.06 µm
  2. 6 µm
  3. 60 µm
  4. 48 600 µm

Answer: C. 60 µm

Actual size = image size ÷ magnification = 54 mm ÷ 900 = 0.06 mm. Converting to micrometres: 0.06 × 1000 = 60 µm. 0.06 µm forgets the conversion; 48 600 µm comes from multiplying by the magnification.

FAQs

Are these official 0610 past-paper questions?

No. They are original questions written to match the Biology syllabus topics. Official past papers are available to schools through Cambridge.

Why choose an exam year?

Cambridge updates syllabuses periodically. Your exam year selects the matching configuration so topics and components follow the right version.

Is a calculator allowed?

In this configuration a scientific calculator is permitted for the listed papers. Check your syllabus for the exact rule.